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BPN-15606 

Cat. No. M29016

All AbMole products are for research use only, cannot be used for human consumption.

BPN-15606  Structure

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Quality Control & Documentation
Biological Activity

BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance.

Chemical Information
Molecular Weight 418.47
Formula C23H23FN6O
CAS Number 1914989-49-3
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, sealed
References

[1] Andrew B Caldwell, et al. Alzheimers Dement. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease

[2] Kevin D Rynearson, et al. J Exp Med. Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention

[3] Olga Prikhodko, et al. J Alzheimers Dis. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease

[4] Steven L Wagner, et al. J Pharmacol Exp Ther. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

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Keywords: BPN-15606  supplier, Gamma-secretase/Beta-secretase, inhibitors, activators

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