About 32 results found for searched term "17-PA" (0.066 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6319 | 17-PA | GABA Receptor |
| 17-PA is a antagonist of neurosteroid potentiation and direct gating of GABA A. | ||
| M9534 | TAS6417 | EGFR/HER2 |
| TAS-6417; Zipalertinib; CLN-081 | ||
| TAS6417 is a novel EGFR inhibitor targeting exon 20 insertion mutations, with IC50 values range from 1.1-8.0 nM. | ||
| M52930 | [Arg-15, 20, 21, Leu17]-PACAP-Gly-Lys-Arg-NH2 | Others |
| [Arg-15,-20,-21,Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) is a synthetic PACAP 1-27 analogue with relaxant effect. | ||
| M1739 | PKI-179 | PI3K |
| PKI-179 is an orally dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor with potential antineoplastic activity. | ||
| M1824 | SRT1720 Hydrochloride | Sirtuin |
| SRT-1720 Hydrochloride | ||
| SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2152 | Carfilzomib | Proteasome |
| PR-171 | ||
| Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of <5 nM. Carfilzomib irreverently selectively binds to the active site containing n-terminal threonine of the 20S proteasome and proteolytic core particles of the 26S proteasome.*The compound is unstable in solutions, freshly prepared is recommended. | ||
| M2576 | VU 0361737 | GluR |
| ML-128 | ||
| VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively. | ||
| M2766 | IEM 1754 dihydrobromide | GluR |
| IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. | ||
| M2912 | Pacritinib | JAK |
| SB1518 | ||
| Pacritinib (SB1518) is an effective mutant inhibitor of wild-type JAK2 and JAK2V617F with IC50 of 23 nM and 19 nM, respectively. Pacritinib also inhibited FLT3 and its mutant FLT3D835Y with IC50 of 22 nM and 6 nM, respectively. | ||
| M3293 | HMN-214 | PLK |
| IVX-214 | ||
| HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1. | ||
| M40977 | ALN-HSD | Hydroxysteroid dehydrogenase |
| ALN-HSD is an siRNA and also an inhibitor of 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13), which can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M4786 | Aristolochic acid A | NF-κB |
| Aristolochic acid I; TR 1736 | ||
| Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. | ||
| M5276 | MK-8617 | HIF |
| MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively. | ||
| M5533 | Corticosterone | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | ||
| Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. | ||
| M5675 | SR3335 | ROR |
| ML 176 | ||
| SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. | ||
| M6044 | Uprosertib (GSK2141795) | Akt |
| GSK795; Uprosertib | ||
| Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1). | ||
| M6077 | LTURM34 | DNA-PK |
| LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM. | ||
| M6087 | LXR-623 | Liver X Receptor |
| WAY-252623 | ||
| LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier. | ||
| M6472 | ATC 0175 hydrochloride | Others |
| ATC 0175 hydrochloride is a mCH 1 antagonist; also 5-HT 2B antagonist and 5-HT 1A partial agonist. | ||
| M6582 | CGP 12177 hydrochloride | Others |
| CGP 12177 hydrochloride is a β 3 partial agonist. β 1/β 2 antagonist. | ||
| M6650 | Daminozide | Histone demethylase |
| DaminoDaminozide is a plant growth regulator and selective inhibitor of human KDM2/7 histone demethylases, with IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively.Daminozide is >100-fold selective for KDM2/7 demethylases compared to other demethylase subfamily members tested. zide is a selective KDM2/7 inhibitor. | ||
| M7362 | TC NTR1 17 | Others |
| TC NTR1 17 is a selective NTS 1 partial agonist. | ||
| M7894 | LY311727 | Others |
| LY311727 is an oral active compound; Phospholipase A2 (sPLA2; Group activity highlights) inhibitors. | ||
| M7897 | L-838,417 | Others |
| L-838,417 is a novel partial agonist that is ineffective against subtype 1 but has the same efficacy against α2, K3 and α5 subtypes. | ||
| M7934 | MDL 28170 | Gamma-secretase/Beta-secretase |
| Calpain Inhibitor III | ||
| Mdl-28170 (Calpain Inhibitor III) is a potent, selective, membrane-permeable Inhibitor of cysteine protease (Calpain Inhibitor III) that can quickly cross the blood-brain barrier after systemic administration. Mdl-28170 also blocks gamma-secretase. | ||
| M8210 | FR-171113 | Others |
| FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. | ||
| M8329 | PD 151746 | Calpain |
| PD151746 | ||
| PD151746 is a calpain inhibitor that selectively inhibits U-calpain (Ki = 0.26 ± 0.03 μM) 20 times more than m-calpain (Ki = 5.33 ± 0.77μM). | ||
| M8389 | SR 27417 | Others |
| SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M8618 | KT172 | Others |
| KT172 is a Diacylglycerol lipase (DAGL) inhibitor selective for DAGLβ. | ||
| M8641 | LP117 | Others |
| LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. | ||
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