About 1 result found for searched term "1454920-20-7" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28489 | MI-2-2 | Epigenetic Reader Domain |
| MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation. | ||
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