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MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.
| Molecular Weight | 415.5 |
| Formula | C17H20F3N5S2 |
| CAS Number | 1454920-20-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | -20°C, protect from light, dry, sealed |
[3] Masoud Vedadi, et al. Protein Sci. Targeting human SET1/MLL family of proteins
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