About 10 results found for searched term "12-HETE" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M31179 | 12-HETE | Apoptosis |
| 12-HETE is a metabolite of arachidonic acid catalyzed by lipoxygenase (12-LOX). It is also a highly selective ligand that can be used to label mu opioid receptors in membrane and tissue sections. In addition, 12-HETE functions as an inhibitor of apoptosis. | ||
| M13658 | STL127705 | DNA-PK |
| STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM). | ||
| M21167 | RMC-5552 | mTOR |
| The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor. | ||
| M21278 | Recombinant Mouse IL-12 (Mammalian) | Recombinant Proteins |
| IL12; NKSF; TCMF; CLMF; TSF | ||
| Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine consisting of p35 and p40 subunits. Measured in a cell proliferation assay using 2D6 cells, the ED50 is < 0.15 ng/ml. | ||
| M25102 | Lusvertikimab | IL Receptor/Related |
| OSE-127 | ||
| Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research. | ||
| M29153 | FKBP12 PROTAC dTAG-7 | PROTAC |
| dTAG-7 | ||
| FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. | ||
| M29154 | FKBP12 PROTAC dTAG-13 | PROTAC |
| dTAG-13 | ||
| FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12F36V and CRBN, thereby selectively degrading FKBP12F36V. | ||
| M29626 | P2X3 antagonist 34 | P2 Receptor |
| P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect. | ||
| M54749 | Recombinant Rat IL-23 Protein (HEK293, C-His) | Recombinant Proteins |
| Interleukin-23; IL-23A; IL-23 alpha & IL-12 beta | ||
| IL-23 (IL-23 alpha & IL-12 beta Heterodimer) Protein is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293. | ||
| M55020 | AZD0780 | PCSK9 |
| PCSK9-IN-12; AZD-0780 | ||
| AZD0780 (PCSK9-IN-12, EX-A6975) is a heteroaryl compound. AZD0780 (PCSK9-IN-12, EX-A6975) has bind affinity for PCSK9 with a Kd value of ＜200 nM. AZD0780 (PCSK9-IN-12, EX-A6975) can be used for the research of cholesterol metabolism. | ||
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