About 3 results found for searched term "(-)-JNJ-A07" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21216 | (+)-JNJ-A07 | Others |
| (+)-JNJ-A07 is a potent pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against 21 clinical isolates. (+)-JNJ-A07 has a good pharmacokinetic profile and showed significant efficacy against dengue virus infection in a mouse infection model. | ||
| M21217 | (-)-JNJ-A07 | Others |
| (-)-JNJ-A07 is a potent and selective inhibitor of dengue virus (DENV) with an EC50 of 31 nM. | ||
| M25542 | JNJ-5207787 | Neuropeptide Receptor |
| JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50 values of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors. | ||
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