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Zuclopenthixol

Cat. No. M13954
Zuclopenthixol Structure
Synonym:

(Z)-Clopenthixol

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Biological Activity

Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist.

Chemical Information
Molecular Weight 400.96
CAS Number 53772-83-1
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Zuclopenthixol

[2] Edward J Bryan, et al. Zuclopenthixol dihydrochloride for schizophrenia

[3] Michael Lacey, et al. Zuclopenthixol versus placebo for schizophrenia

[4] Kaushadh Jayakody, et al. Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses

[5] A Kumar, et al. Zuclopenthixol dihydrochloride for schizophrenia

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