Free shipping on all orders over $ 500

Zuclopenthixol

Cat. No. M13954
Zuclopenthixol Structure
Synonym:

(Z)-Clopenthixol

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 400.96
Formula
CAS Number 53772-83-1
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] No authors listed. Zuclopenthixol

[2] Edward J Bryan, et al. Zuclopenthixol dihydrochloride for schizophrenia

[3] Michael Lacey, et al. Zuclopenthixol versus placebo for schizophrenia

[4] Kaushadh Jayakody, et al. Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses

[5] A Kumar, et al. Zuclopenthixol dihydrochloride for schizophrenia

Related Dopamine Receptor Products
TAK-906

TAK-906 is a peripherally restricted, non-BBB permeable molecule that targets the posterior region of the stomach and vomiting center for the study of gastric cramps.

LY3154885

LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM).

ONC206

ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity.

Trifluoperazine

Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.

Tiapride Hydrochloride

Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.

  Catalog
Abmole Inhibitor Catalog




Keywords: Zuclopenthixol, (Z)-Clopenthixol supplier, Dopamine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.