Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.
|Solubility (25°C)||DMSO 61 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 E C Rodriguez-Merchan. Postgrad Med. Topical therapies for knee osteoarthritis
 Kinga Sałat, et al. Expert Opin Investig Drugs. Zucapsaicin for the treatment of neuropathic pain
 M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
 D O Arnar, et al. J Cardiovasc Pharmacol. Electrophysiologic effects of civamide (zucapsaicin) on canine cardiac tissue in vivo and in vitro
 J Lu, et al. J Chromatogr B Biomed Sci Appl. Determination of capsaicin and zucapsaicin in human serum by high-performance liquid chromatography with fluorescence detection
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Vocacapsaicin (CA-008) hydrochloride, as a prodrug of capsaicin, is the first non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride provides lasting pain relief.
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