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Zucapsaicin

Cat. No. M20954
Zucapsaicin Structure
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Biological Activity

Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.

Chemical Information
Molecular Weight 305.41
Formula C18H27NO3
CAS Number 25775-90-0
Solubility (25°C) DMSO 61 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] E C Rodriguez-Merchan. Postgrad Med. Topical therapies for knee osteoarthritis

[2] Kinga Sałat, et al. Expert Opin Investig Drugs. Zucapsaicin for the treatment of neuropathic pain

[3] M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

[4] D O Arnar, et al. J Cardiovasc Pharmacol. Electrophysiologic effects of civamide (zucapsaicin) on canine cardiac tissue in vivo and in vitro

[5] J Lu, et al. J Chromatogr B Biomed Sci Appl. Determination of capsaicin and zucapsaicin in human serum by high-performance liquid chromatography with fluorescence detection

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