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ZM 39923 hydrochloride

Cat. No. M3141
ZM 39923 hydrochloride Structure
Size Price Availability Quantity
10mg USD 110  USD110 In stock
50mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

ZM 39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923, a Janus kinase inhibitor,is the most potent inhibitors with IC(50) of 10 and 5 nM, respectively.ZM 39923 Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829.

Chemical Information
Molecular Weight 367.91
Formula C23H25NO.HCl
CAS Number 1021868-92-7
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lai TS, et al. Chem Biol. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.

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ZM39923

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

  Catalog
Abmole Inhibitor Catalog




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