Zeatin is a coconut milk-derived plant hormone and is a common plant cytokinin that is found in the developing or meristematic tissues and organs such as roots, shoot apex, immature organs, and others. Zeatin promotes the growth of lateral buds and stimulates cell division (lateral dominance), callus initiation, and seed germination. Zeatin is used with Murashige and Skoog and other media. Zeatin promotes multiple shoot generation from internodes and high-frequency thick-spread roots.
| Molecular Weight | 219.24 |
| Formula | C10H13N5O |
| CAS Number | 13114-27-7 |
| Solubility (25°C) | Soluble in sodium hydroxide |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Paula Elizabeth Jameson. Plant Physiol. Zeatin: The 60th anniversary of its identification
[2] Xin Sun, et al. J Org Chem. Photo- and Tetrazine-Responsive Modulation of trans-Zeatin
[4] Rostislav A Streletskii, et al. PeerJ. Yeasts producing zeatin
[5] Motoyuki Ashikari, et al. Science. Cytokinin oxidase regulates rice grain production
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