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ZD0947

Cat. No. M8778

All AbMole products are for research use only, cannot be used for human consumption.

ZD0947 Structure

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Biological Activity

ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.

Chemical Information
Molecular Weight 318.29
Formula C17H13F3N2O
CAS Number 172649-40-0
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tadashi Yamamoto, et al. ZD0947, a sulphonylurea receptor modulator, detects functional sulphonylurea receptor subunits in murine vascular smooth muscle ATP-sensitive K + channels

[2] Keisuke Mori, et al. Effects of ZD0947, a novel and potent ATP-sensitive K + channel opener, on smooth muscle-type ATP-sensitive K + channels

[3] Takakazu Yunoki, et al. Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles

[4] M Aishima, et al. Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes

[5] Aly M Abdel-Karim, et al. Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats

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Keywords: ZD0947 supplier, inhibitors, activators

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