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YM-26734 is a competitive inhibitor of the secreted (Group II) form of phospholipase A2. The IC50 against rabbit platelet derived sPLA2 is 85 nM. YM-26734 is active against, but less potent for group I (pancreatic) sPLA2 (porcine pancreatic enzyme IC50 = 7 μM), and does not inhibit intracellular PLA2 isoforms.
| Molecular Weight | 730.97 |
| Formula | C45H62O8 |
| CAS Number | 144337-18-8 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] V D Mouchlis, et al. The application of rational design on phospholipase A(2) inhibitors
[2] Rob C Oslund, et al. Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA
[3] U Tibes, et al. Phospholipase A2 inhibitors in development
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