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Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.
| Molecular Weight | 276.29 |
| Formula | C14H16N2O4 |
| CAS Number | 127408-31-5 |
| Solubility (25°C) | 1eq. NaOH 27.63 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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