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XT2 

Cat. No. M29717

All AbMole products are for research use only, cannot be used for human consumption.

XT2  Structure

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Quality Control & Documentation
Biological Activity

XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases.

Chemical Information
Molecular Weight 379.41
Formula C19H14FN5OS
CAS Number 2582816-37-1
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nobuhiro Sasaki, et al. Plant J. Identification and characterization of xanthone biosynthetic genes contributing to the vivid red coloration of red-flowered gentian

[2] Baiqing You, et al. Phys Chem Chem Phys. Black phosphorene/monolayer transition-metal dichalcogenides as two dimensional van der Waals heterostructures: a first-principles study

[3] Dustin Singer, et al. J Biol Chem. Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3

[4] François Verrey, et al. Pflugers Arch. Kidney amino acid transport

[5] Hui Quan, et al. Mol Cell Biol. Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2

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  Catalog
Abmole Inhibitor Catalog




Keywords: XT2  supplier, inhibitors, activators

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