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XL019

Cat. No. M2566
XL019 Structure
Size Price Availability Quantity
10mM*1mL USD 126  USD140 In stock
5mg USD 99  USD110 In stock
10mg USD 162  USD180 In stock
50mg USD 495  USD550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2.

Customer Product Validations & Biological Datas
Source Anticancer Res (2017). Figure 2. XL019
Method fluorescence-activated cell sorting analyses
Cell Lines KBV20C cancer cells
Concentrations 5 μM
Incubation Time 24 h
Results As shown in Figure 2A, co-treatment with XL019 and vincristine increased the number of cells arrested in the G2 phase compared to that observed with single treatments with either agent.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 444.53
Formula C25H28N6O2
CAS Number 945755-56-6
Purity >98%
Solubility DMSO 15 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: XL019 supplier, JAK, inhibitors

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