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WWL229

Cat. No. M8466

All AbMole products are for research use only, cannot be used for human consumption.

WWL229 Structure

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Quality Control & Documentation
Biological Activity

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

Chemical Information
Molecular Weight 322.36
Formula C16H22N2O5
CAS Number 1338575-28-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hannah L Scheaffer, et al. Inactivation of CES1 Blocks Prostaglandin D 2 Glyceryl Ester Catabolism in Monocytes/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E 2 Glyceryl Ester Are Attenuated

[2] Li Yang, et al. A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis

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  Catalog
Abmole Inhibitor Catalog




Keywords: WWL229 supplier, inhibitors, activators

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