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VUAA1

Cat. No. M8499

All AbMole products are for research use only, cannot be used for human consumption.

VUAA1 Structure

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Quality Control & Documentation
Biological Activity

VUAA1 is an agonist of the highly conserved insect odorant receptor co-receptor ion channel Orco. VUAA1 is able to activate both heteromeric and homomeric Orco-containing channels, acting as an insect repellant by over-activating an insect′s olfactory senses causing a repellent effect.

Chemical Information
Molecular Weight 367.47
Formula C19H21N5OS
CAS Number 525582-84-7
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kalpana Jain, et al. Calmodulin regulates the olfactory performance in Drosophila melanogaster

[2] Liu Yang, et al. Bioactivities and modes of action of VUAA1

[3] Jacob A Corcoran, et al. Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor

[4] Brijesh N Kumar, et al. A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco)

[5] Patrick L Jones, et al. Allosteric antagonism of insect odorant receptor ion channels

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Keywords: VUAA1 supplier, inhibitors, activators

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