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VUAA1 is an agonist of the highly conserved insect odorant receptor co-receptor ion channel Orco. VUAA1 is able to activate both heteromeric and homomeric Orco-containing channels, acting as an insect repellant by over-activating an insect′s olfactory senses causing a repellent effect.
| Molecular Weight | 367.47 |
| Formula | C19H21N5OS |
| CAS Number | 525582-84-7 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Kalpana Jain, et al. Calmodulin regulates the olfactory performance in Drosophila melanogaster
[2] Liu Yang, et al. Bioactivities and modes of action of VUAA1
[5] Patrick L Jones, et al. Allosteric antagonism of insect odorant receptor ion channels
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