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VU0405601

Cat. No. M8403

All AbMole products are for research use only, cannot be used for human consumption.

VU0405601 Structure

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Quality Control & Documentation
Biological Activity

VU0405601 is a hERG (the human Ether-à-go-go-Related Gene) agonist that increased the IC50 of dofetilide from 38.7 nM to 76.3 nM. VU0405601 protects against arrhythmias induced by hERG inhibition.

Chemical Information
Molecular Weight 357.2
Formula C17H13BrN2O2
CAS Number 712325-30-9
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christian Egly, et al. A High-throughput Assay to Identify Drugs that can Treat Long QT Syndrome Caused by Trafficking-deficient K V 11.1 (hERG) Variants

[2] Zhiyi Yu, et al. Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias

[3] Zhiyi Yu, et al. Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

[4] Franck Potet, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias

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Keywords: VU0405601 supplier, inhibitors, activators

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