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VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.
| Molecular Weight | 326.39 |
| Formula | C18H22N4O2 |
| CAS Number | 333415-38-6 |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jelena Sikimic, et al. Possible New Strategies for the Treatment of Congenital Hyperinsulinism
[5] Rene Raphemot, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative
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