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VU 0483605 is a positive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.
| Molecular Weight | 446.67 |
| Formula | C20H10Cl3N3O3 |
| CAS Number | 1623101-11-0 |
| Solubility (25°C) | DMSO 22.33 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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