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Seviteronel

Cat. No. M28670

All AbMole products are for research use only, cannot be used for human consumption.

Seviteronel Structure
Synonym:

VT-464

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Quality Control & Documentation
Biological Activity

Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.

Chemical Information
Molecular Weight 399.34
Formula C18H17F4N3O3
CAS Number 1610537-15-9
Form Solid
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ravi A Madan, et al. Clin Genitourin Cancer. Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment

[2] Anna R Michmerhuizen, et al. Front Endocrinol (Lausanne). Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells

[3] Cody J Peer, et al. Cancer Chemother Pharmacol. A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer

[4] Shilpa Gupta, et al. Clin Cancer Res. Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer

[5] Aditya Bardia, et al. Breast Cancer Res Treat. Phase 1 study of seviteronel, a selective CYP17 lyase and androgen receptor inhibitor, in women with estrogen receptor-positive or triple-negative breast cancer

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Abmole Inhibitor Catalog




Keywords: Seviteronel, VT-464 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators

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