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Vocacapsaicin

Cat. No. M21477
Vocacapsaicin Structure
Synonym:

CA-008

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Biological Activity

Vocacapsaicin (CA-008), a prodrug of capsaicin, is the first (first-in-class) non-opioid TRPV1 agonist. Vocacapsaicin can provide lasting pain relief.

Chemical Information
Molecular Weight 459.62
Formula C26H41N3O4
CAS Number 1931116-86-7
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Olle Lwhagen. J Asthma. Diagnosis of asthma - new theories

[2] Peter G Gibson, et al. Pulm Pharmacol Ther. Speech pathology for chronic cough: a new approach

[3] Peter Gerner, et al. Anesthesiology. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve

[4] I-Jung Lu, et al. J Appl Physiol (1985). Capsaicin-induced activation of pulmonary vagal C fibers produces reflex laryngeal closure in the rat

[5] D B Masters, et al. Physiol Behav. Neonatal capsaicin treatment attenuates sensory-induced analgesia and nociception

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Keywords: Vocacapsaicin, CA-008 supplier, TRP Channel, inhibitors, activators


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