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Vitamin E (D-alpha-Tocopherol)

Cat. No. M6057
Vitamin E (D-alpha-Tocopherol) Structure
Synonym:

(+)-α-Tocopherol; D-α-Tocopherol;α-Vitamin E

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Vitamin E (D-alpha-Tocopherol) is a naturally occurring form of Vitamin E that is a potent antioxidant.

Chemical Information
Molecular Weight 430.71
Formula C29H50O2
CAS Number 59-02-9
Solubility (25°C) 10 mM in DMSO
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peh HY, et al. Pharmacol Ther. Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol.

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Keywords: Vitamin E (D-alpha-Tocopherol), (+)-α-Tocopherol; D-α-Tocopherol;α-Vitamin E supplier, COX, inhibitors, activators


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