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Vibsanin A 

Cat. No. M30542
Vibsanin A  Structure
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Biological Activity

Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor.

Chemical Information
Molecular Weight 402.57
Formula C25H38O4
CAS Number 72506-14-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Kazuki Miura, et al. Bioorg Med Chem. Identification of vibsanin A analog as a novel HSP90 inhibitor

[2] Xing Shen, et al. Biochem Biophys Res Commun. Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

[3] Wataru Matsuki, et al. Bioorg Med Chem Lett. Synthesis and evaluation of biological activities of vibsanin A analogs

[4] Zu-Yin Yu, et al. Cancer Res. Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation

[5] Ken-ichi Takao, et al. Org Lett. Total synthesis of (+)-vibsanin A

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Keywords: Vibsanin A  supplier, PKC, inhibitors, activators

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