Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP).
| Molecular Weight | 2865.37 |
| Formula | C123H198N36O36S3 |
| CAS Number | 141676-35-9 |
| Solubility (25°C) | Water |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related PKG Products |
|---|
| PKG Substrate
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). |
| PKG inhibitor peptide
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM. |
| G-Subtide
G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. |
| Rp-8-pCPT-cGMPS sodium
Rp-8-pCPT-cGMPS sodium is a pKG inhibitor. |
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