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Vancomycin HCl

Cat. No. M4862
Vancomycin HCl Structure
Synonym:

Vancocin HCl

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 65  USD65 In stock
100mg USD 40  USD40 In stock
250mg USD 60  USD60 In stock
1g USD 110  USD110 In stock
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Quality Control & Documentation
  • Purity: Antibiotic Titer ≥900μg/mg, USP33
  • COA
  • MSDS
  • H-NMR
Biological Activity

Vancomycin hydrochloride (Vancocin) is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. Due to the different mechanism by which Gram-negative bacteria produce their cell walls and the various factors related to entering the outer membrane of Gram-negative organisms, vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria).

Product Citations
Chemical Information
Molecular Weight 1485.71
Formula C66H75Cl2N9O24.HCl
CAS Number 1404-93-9
Solubility (25°C) Water ≥ 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring

[2] Roco lvarez, et al. Optimizing the Clinical Use of Vancomycin

[3] Donald P Levine. Vancomycin: a history

[4] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin

[5] M P Wilhelm. Vancomycin

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Keywords: Vancomycin HCl, Vancocin HCl supplier, Antibiotic, inhibitors, activators


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