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Vancomycin hydrochloride (Vancocin) is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. Due to the different mechanism by which Gram-negative bacteria produce their cell walls and the various factors related to entering the outer membrane of Gram-negative organisms, vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria).
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Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Vancomycin HCl purchased from AbMole
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Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration
Vancomycin HCl purchased from AbMole
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Interaction between gut microbiota dysbiosis and lung infection as gut-lung axis caused by Streptococcus suis in mouse model
Vancomycin HCl purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Vero cells |
| Preparation method | Cells were seeded in each well of 24 well-plates and incubated under the same conditions and divided into three major groups in triplicates. One control group Cn was left untreated while group DMSO was treated with 0.1% DMSO. Vancomycin treated groups were divided into V1 (0.6 mg/mL), V2 (3.0 mg/mL), and V3 (6.0 mg/mL) to find out the cytotoxic effect of the antibiotic after 24hrs of vancomycin treatment. |
| Concentrations | 0.6 mg/mL - 6 mg/mL |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c male mice |
| Formulation | dd H2O |
| Dosages | 0.5 g/L dissolved in drinking water |
| Administration | Oral |
| Molecular Weight | 1485.71 |
| Formula | C66H75Cl2N9O24.HCl |
| CAS Number | 1404-93-9 |
| Solubility (25°C) | Water ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring
[2] Donald P Levine. Vancomycin: a history
[3] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin
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|---|
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Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group which inhibiting bacterial DNA replication. |
| Sulfadimethoxine
Sulfadimethoxine (trade name Di-Methox, Albon) is a sulfonamide antibiotic. |
| Natamycin
Natamycin is an antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. |
| Teicoplanin
Teicoplanin is a long-acting glycopeptide antibiotic derived from actinomycetes that inhibits cell wall synthesis and interferes with the process of synthesizing new portions of peptidoglycan, and has a good inhibitory effect on gram-positive pathogens (including staphylococcal biofilms). |
| Biapenem
Biapenem is a new parenteral carbapenem antibacterial agent with a broad spectrum of in vitro antibacterial activity. |
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