Vancomycin hydrochloride (Vancocin) is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. Due to the different mechanism by which Gram-negative bacteria produce their cell walls and the various factors related to entering the outer membrane of Gram-negative organisms, vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria).
ACS Nano. 2023 Mar 30.
Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration
Vancomycin HCl purchased from AbMole
Microbiol Res. 2022 Aug;261:127047.
Interaction between gut microbiota dysbiosis and lung infection as gut-lung axis caused by Streptococcus suis in mouse model
Vancomycin HCl purchased from AbMole
| Molecular Weight | 1485.71 |
| Formula | C66H75Cl2N9O24.HCl |
| CAS Number | 1404-93-9 |
| Solubility (25°C) | Water: ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring
[2] Roco lvarez, et al. Optimizing the Clinical Use of Vancomycin
[3] Donald P Levine. Vancomycin: a history
[4] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin
| Related Antibiotic Products |
|---|
| Arylomycin A2
Arylomycin A2 is an antibiotic and lipopeptide type I signal peptidase (SPase I) inhibitor with antibacterial activity. |
| Bleomycin A2 sulfate
Bleomycin A2 sulfate is an antitumor antibiotic that promotes DNA degradation and is also an aspartate/asparagine-β-hydroxylase (AspH) inhibitor with an IC50 of 1.47 μM. |
| G0775
G0775 is a novel antibiotic that penetrates the outer membrane through a porin-independent mechanism and exhibits potent, broad-spectrum antibacterial activity against Gram-negative bacteria. |
| Malacidin B
Malacidin B is a macrocyclic lipopeptide antibiotic that exerts antimicrobial activity in a calcium-dependent manner. |
| Malacidin A
Malacidin A is a calcium-dependent antibiotic that is highly active against many drug-resistant pathogens, especially Gram-positive bacteria. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
