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Valiolamine

Cat. No. M30668
Valiolamine Structure
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Biological Activity

Valiolamine is an aminocyclitol. Valiolamine has potent alpha-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase.

Chemical Information
Molecular Weight 193.2
Formula C7H15NO5
CAS Number 83465-22-9
Form Solid
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sharanbasappa S Karade, et al. J Med Chem. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity

[2] Bum-Ho Bin, et al. Int J Mol Sci. Novel inhibitory effect of N-(2-hydroxycyclohexyl)valiolamine on melanin production in a human skin model

[3] Seiichiro Ogawa, et al. J Nat Prod. Synthesis of valiolamine and some precursors for bioactive carbaglycosylamines from (-)-vibo-quercitol produced by biogenesis of myo-inositol

[4] Y Kameda, et al. J Antibiot (Tokyo). Valiolamine, a new alpha-glucosidase inhibiting aminocyclitol produced by Streptomyces hygroscopicus

[5] M Takeuchi, et al. Chem Pharm Bull (Tokyo). Inhibitory effect of validamine, valienamine and valiolamine on activities of carbohydrases in rat small intestinal brush border membranes

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Keywords: Valiolamine supplier, inhibitors, activators

 
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