Free shipping on all orders over $ 500

Valategrast

Cat. No. M29354

All AbMole products are for research use only, cannot be used for human consumption.

Valategrast Structure
Synonym:

R-411 free base

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

Chemical Information
Molecular Weight 604.95
Formula C30H32Cl3N3O4
CAS Number 220847-86-9
Form Solid
Solubility (25°C) DMSO 170 mg/mL (ultrasonic)
Storage -80°C, sealed
References

[1] Nis Halland, et al. ACS Med Chem Lett. Small Macrocycles As Highly Active Integrin α2β1 Antagonists

[2] Darren G Woodside, et al. BioDrugs. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease

Related Integrin Products
Volociximab

Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC50=0.2 nM). Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs).

GSK 3008348 hydrochloride 

GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist.

HSDVHK-NH2

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM).

LDV

LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC.

Cyclo(RADfK)

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

  Catalog
Abmole Inhibitor Catalog




Keywords: Valategrast, R-411 free base supplier, Integrin, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.