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Vedolizumab

Cat. No. M1618
Vedolizumab Structure
Synonym:

MLN-02; LDP-02; MLN0002

Size Price Availability Quantity
2mg USD 560  USD560 In stock
5mg USD 740  USD740 In stock
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Quality Control & Documentation
Biological Activity

Vedolizumab is a humanized monoclonal antibody that specifically antagonizes Integrin (α4β7) and inhibits the binding of α4β7 to the intestinal mucosal cell adhesion molecule MADCAM-1. Vedolizumab is indicated for humanized mice.

Chemical Information
Molecular Weight 146834.53
Formula C6528H10072N1732O2042S42
CAS Number 943609-66-3
Storage -80°C for long term
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fedyk ER, et al. Inflamm Bowel Dis. Exclusive antagonism of the α4 β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.

[2] Soler D, et al. J Pharmacol Exp Ther. The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases.

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Keywords: Vedolizumab, MLN-02; LDP-02; MLN0002 supplier, Integrin, inhibitors, activators


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