RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
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Source | Sci Rep (2018). Figure 1. RGD |
| Method | measuring fluorescence intensity | |
| Cell Lines | U87MG and K562 cells | |
| Concentrations | 200 nM | |
| Incubation Time | 7 h | |
| Results | Figure 2a shows cellular uptake of PSs at various concentrations in U87MG cells. The 700DX-PEG-cRGD, 700DX-PEG-PGlu-cRGD5, and 700DX-PEG-PGlu-cRGD15 revealed significantly high cellular uptake depending on the number of cRGD peptides, while no significant difference could be obtained between free 700DX and 700DX-PEG-PGlu-cRAD15. |
| Molecular Weight | 346.34 |
| Formula | C12H22N6O6 |
| CAS Number | 99896-85-2 |
| Solubility (25°C) | Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Meng Yang, et al. Function and Mechanism of RGD in Bone and Cartilage Tissue Engineering
[4] Sotirios Katsamakas, et al. RGD-mediated delivery of small-molecule drugs
[5] E Ruoslahti. RGD and other recognition sequences for integrins
| Related Integrin Products |
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| HSDVHK-NH2
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM). |
| LDV
LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC. |
| Cyclo(RADfK)
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. |
| Obtustatin
Obtustatin is a non-RGD disintegrin of 41 residues. |
| Integrin Binding Peptide
Integrin Binding Peptide is derived by fibronectin. |
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