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Valaciclovir inhibits the uptake of substrates of dipeptide transporters, such as cefalexin. The metabolism of Valaciclovir to Aciclovir probably occurs within the gut lumen prior to absorption, in the small intestine after uptake but before entry into the portal blood system, and in the liver before entry into systemic circulation.Valaciclovir, the L-valyl ester of acyclovir (ZOVIRAX), demonstrates good oral absorption and nearly complete conversion to acyclovir incynomolgus monkeys, indicating its suitability as an orally administered prodrug.
| Molecular Weight | 360.8 |
| Formula | C13H21ClN6O4 |
| CAS Number | 124832-27-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 14 mg/ml Water 72 mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] MacDougall C,et.al. J Antimicrob Chemother. Pharmacokinetics of valaciclovir.
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