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Val-Cit-PAB-MMAE is a MMAE derivative with a cleavable linker, which is useful to make MMAE conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. MMAE is a potent mitotic inhibitor by inhibiting tubulin polymerization.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 1123.43 |
| Formula | C58H94N10O12 |
| CAS Number | 644981-35-1 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 2-8°C, sealed |
| Related Drug-Linker Conjugates for ADC Products |
|---|
| MC-SN38
MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). |
| DM4-SMCC
DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker. |
| Lys-SMCC-DM1
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. |
| Doxorubicin-SMCC
Doxorubicin-SMCC is a agent-linker conjugate for ADC. |
| Mal-PEG4-VC-PAB-DMEA-PNU-159682
Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. |
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