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UVI3003 is a high-affinity selective Pan-retinoid X receptor (RXR) full antagonist. Retinoid actions are predominantly mediated through the formation of various RAR and RXR isotype heterodimers that can act as either transcriptional repressors or activators. UVI3003 has been used as a tool to test the contribution of RXR to transactivation by a given RXR heterodimer. It was found to induce teratogenesis in zebrafish embryos and recently was found to inhibit A?42 aggregation.
| Molecular Weight | 436.58 |
| Formula | C28H36O4 |
| CAS Number | 847239-17-2 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related RAR/RXR Products |
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| YCT529
YCT529 is a potent, selective and orally active RAR-α inhibitor. |
| LG101506
LG101506 is a selective and orally active RXR modulator with a Ki of 2.7 nM for RXRα. |
| ER 50891
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). |
| LG100754
LG100754 (UVI 2112) is a RXR dimers modulater. |
| AGN 196996
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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