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Uridine triphosphate trisodium

Cat. No. M3816
Uridine triphosphate trisodium Structure
Synonym:

UTP Trisodium Salt; Uridine 5'-triphosphate

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Uridine triphosphate trisodium (UTP;Uridine 5'-triphosphate) is a nucleotide.

Chemical Information
Molecular Weight 550.09
Formula C9H12N2Na3O15P3
CAS Number 19817-92-6
Solubility (25°C) Water ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lamarca A, et al. PLoS One. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.

[2] Iwaki Y, et al. Microbes Infect. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice.

[3] Choi JH, et al. Pancreas. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.

[4] Yitzhaki S, et al. Biochem Pharmacol. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct.

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Keywords: Uridine triphosphate trisodium, UTP Trisodium Salt; Uridine 5'-triphosphate supplier, inhibitors, activators


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