Free shipping on all orders over $ 500

URAT1 inhibitor 7

Cat. No. M42270
URAT1 inhibitor 7 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

URAT1 inhibitor 7 is a potent URAT1 inhibitor, with an IC50 of 12 nM.

Chemical Information
Molecular Weight 428.82
Formula C19H10ClFN4O3S
CAS Number 1632002-28-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jordana Dinorá de Lima et al. Immunol Invest. Genetic and Epigenetic Regulation of the Innate Immune Response to Gout

[2] Qian Ren et al. Phytomedicine. Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling

[3] Ze-An Zhao et al. Acta Pharmacol Sin. CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia

[4] Thomas Bardin et al. Rheumatology (Oxford). Novel uricosurics

[5] Hiroshi Miyata et al. Front Pharmacol. Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations

Related URAT1 Products
KPH2f

KPH2f is an orally potent dual URAT1/GLUT9 inhibitor, with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively.KPH2f had little effect on OAT1 and ABCG2 (IC50s of 32.14 and 26.74 μM, respectively).
URAT1 inhibitor 8

URAT1 inhibitor 8 is a potent URAT1 inhibitor with an IC50 of 0.001 μM.URAT1 inhibitor 8 can be used in gout related studies.
URAT1 inhibitor 1

URAT1 inhibitor 1 is a uric acid transporter 1 (URAT1) inhibitor with an IC50 value of 32 nM for inhibition of uric acid transporter 1 (URAT1).It can be used in studies related to hyperuricemia and gout.
URAT1 inhibitor 3

URAT1 inhibitor 3 is an orally potent and selective URAT1 inhibitor with an IC50 value of 0.8 nM.URAT1 inhibitor 3 has a uric acid lowering effect and can be used in studies related to gout and hyperuricemia.
AR882

AR882 is a potential best-in-class (BIC), selective inhibitor of uric acid transporter protein 1 (URAT1) for studies related to hyperuricemia and gout.
  Catalog
Abmole Inhibitor Catalog




Keywords: URAT1 inhibitor 7 supplier, URAT1, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.