Unoprostone is a prostaglandin F2α analog (PGAs) that reduces oxidative stress and light-induced retinal cell death as well as phagocytosis dysfunction by activating BK channels. It can be used in studies related to glaucoma or hypertension.
| Molecular Weight | 382.53 |
| Formula | C22H38O5 |
| CAS Number | 120373-36-6 |
| Solubility (25°C) | DMF 25 mg/mL DMSO 17 mg/mL Ethanol 12 mg/mL |
| Storage | -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| 15-keto-Prostaglandin E2
15-keto-Prostaglandin E2 is an endogenous metabolite. |
| Prostaglandin B1
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1. |
| EP3 antagonist 4
EP3 antagonist 4 is an EP3 antagonist, with a Ki value of 2 nM for hEP. |
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