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UNC2250

Cat. No. M3108

All AbMole products are for research use only, cannot be used for human consumption.

UNC2250 Structure
Size Price Availability Quantity
10mg USD 120  USD120 In stock
50mg USD 420  USD420 In stock
100mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

Protocol (for reference only)
Cell Experiment
Cell lines BT-12 rhabdoid tumor cells, and Colo699 NSCLC cells
Preparation method Culturing BT-12 rhabdoid tumor cells (10 000 cells) in 2.0 mL of 0.35% soft agar containing 0.5× RPMI medium, 7.5% FBS, and the indicated concentrations of 10 or DMSO vehicle only and overlaid with 0.5 mL of 1× RPMI medium containing 15% FBS and 10 or DMSO vehicle only. Refreshing medium and 10 or vehicle twice a week. Staining colonies with thiazolyl blue tetrazolium bromide and counting after 3 weeks. Colo699 NSCLC cells (15 000 cells) are cultured in 1.5 mL of 0.35% soft agar containing 1× RPMI medium and 10% FBS and overlaid with 2.0 mL of 1× RPMI medium containing 10% FBS and the indicated concentrations of 10 or DMSO vehicle only. Refreshing medium and 10 or vehicle 3 times per week.Staining colonies with nitrotetrazolium blue chloride and counting after 2 weeks.
Concentrations ~3 μM for BT-12, ~300 nM for Colo699
Incubation time 3 weeks for BT-12, 2 weeks for Colo699
Animal Experiment
Animal models Mice
Formulation
Dosages ~3 mg/kg
Administration i.v. or p.o.
Chemical Information
Molecular Weight 440.58
Formula C24H36N6O2
CAS Number 1493694-70-4
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yuanfeng Du, et al. MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy

[2] Monira Hoque, et al. MerTK activity is not necessary for the proliferation of glioblastoma stem cells

[3] Miki Furukawa, et al. A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD

[4] Cunzhen Shi, et al. The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma

[5] Weihe Zhang, et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors

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  Catalog
Abmole Inhibitor Catalog




Keywords: UNC2250 supplier, TAM Receptor, inhibitors, activators

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