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Cat. No. M3108

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UNC2250 Structure
Size Price Availability Quantity
10mg USD 120  USD120 In stock
50mg USD 420  USD420 In stock
100mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

Protocol (for reference only)
Cell Experiment
Cell lines BT-12 rhabdoid tumor cells, and Colo699 NSCLC cells
Preparation method Culturing BT-12 rhabdoid tumor cells (10 000 cells) in 2.0 mL of 0.35% soft agar containing 0.5× RPMI medium, 7.5% FBS, and the indicated concentrations of 10 or DMSO vehicle only and overlaid with 0.5 mL of 1× RPMI medium containing 15% FBS and 10 or DMSO vehicle only. Refreshing medium and 10 or vehicle twice a week. Staining colonies with thiazolyl blue tetrazolium bromide and counting after 3 weeks. Colo699 NSCLC cells (15 000 cells) are cultured in 1.5 mL of 0.35% soft agar containing 1× RPMI medium and 10% FBS and overlaid with 2.0 mL of 1× RPMI medium containing 10% FBS and the indicated concentrations of 10 or DMSO vehicle only. Refreshing medium and 10 or vehicle 3 times per week.Staining colonies with nitrotetrazolium blue chloride and counting after 2 weeks.
Concentrations ~3 μM for BT-12, ~300 nM for Colo699
Incubation time 3 weeks for BT-12, 2 weeks for Colo699
Animal Experiment
Animal models Mice
Dosages ~3 mg/kg
Administration i.v. or p.o.
Chemical Information
Molecular Weight 440.58
Formula C24H36N6O2
CAS Number 1493694-70-4
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Yuanfeng Du, et al. MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy

[2] Monira Hoque, et al. MerTK activity is not necessary for the proliferation of glioblastoma stem cells

[3] Miki Furukawa, et al. A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD

[4] Cunzhen Shi, et al. The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma

[5] Weihe Zhang, et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors

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Abmole Inhibitor Catalog

Keywords: UNC2250 supplier, TAM Receptor, inhibitors, activators

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