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RU-301

Cat. No. M9385

All AbMole products are for research use only, cannot be used for human consumption.

RU-301 Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 530  USD530 In stock
25mg USD 860  USD860 In stock
50mg USD 1300  USD1300 In stock
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Quality Control & Documentation
Biological Activity

RU-301 is a pan-TAM receptor inhibitor, with Kd and IC50 values of 12 μM and 10 μM, respectively. RU-301 exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis.

Chemical Information
Molecular Weight 480.46
Formula C21H19F3N4O4S
CAS Number 1110873-99-8
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kimani SG, et al. Sci Rep. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity.

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  Catalog
Abmole Inhibitor Catalog




Keywords: RU-301 supplier, TAM Receptor, inhibitors, activators

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