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RU-301 is a pan-TAM receptor inhibitor, with Kd and IC50 values of 12 μM and 10 μM, respectively. RU-301 exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis.
| Molecular Weight | 480.46 |
| Formula | C21H19F3N4O4S |
| CAS Number | 1110873-99-8 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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