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Cat. No. M2180

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SGI-7079 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 60  USD60 In stock
5mg USD 90  USD90 In stock
10mg USD 145  USD145 In stock
50mg USD 565  USD565 In stock
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Quality Control & Documentation
Biological Activity

SGI-7079 is a novel Axl inhibitor. SGI-7079 decreased IBC cell proliferation, migration and invasion in vitro and inhibited tumor growth of IBC cells in vivo. Mesenchymal cells also expressed increased levels of the receptor tyrosine kinase Axl and showed a trend toward greater sensitivity to the Axl inhibitor SGI-7079, whereas the combination of SGI-7079 with erlotinib reversed erlotinib resistance in mesenchymal lines expressing Axl and in a xenograft model of mesenchymal NSCLC.

Customer Product Validations & Biological Datas
Source Cancer Res (2013). Figure 6. SGI-7079
Method MTT
Cell Lines SUM149 cells
Concentrations 1 mmol/L
Incubation Time 72 h
Results SGI-7079 treatment inhibited the phosphorylation of Axl at Tyr 702 upon Gas6 stimulation in SUM149 cells
Protocol (for reference only)
Cell Experiment
Cell lines Mouse ID8 ovarian cancer, TC1 lung cancer, 4T1 breast cancer and CT26 colorectal cancer cells
Preparation method Cell proliferation assay
Cells were plated in 96-well plates (5 × 103/well) and then transfected with siNC or siAxl using Lipofectamine 2000 according to the manufacturer's instructions or treated with vehicle, R428 or SGI-7079 at indicated concentrations. After 72 hours of treatment, cell proliferation assays were performed using Cell Counting Kit-8 according to the manufacturer's instructions. Absorbance was measured at 490 nm using a microplate reader (Molecular devices). The percentage of cell survival was defined as the relative absorbance of untreated versus treated cells.
Concentrations -
Incubation time 72 hours
Animal Experiment
Animal models BALB/c syngeneic mice or nude mice
Formulation formulated in 0.5% hydroxypropylmethylcellulose plus 0.1% Tween 80
Dosages 50 mg/kg
Administration orally
Chemical Information
Molecular Weight 455.53
Formula C26H26FN7
CAS Number 1239875-86-5
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Zhiqiang Guo, et al. Oncotarget. Axl inhibition induces the antitumor immune response which can be further potentiated by PD-1 blockade in the mouse cancer models

[2] Wang X, et al. Cancer Res. TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase.

[3] Byers LA, et al. Clin Cancer Res. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.

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Abmole Inhibitor Catalog

Keywords: SGI-7079 supplier, TAM Receptor, inhibitors, activators

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