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UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).
| Molecular Weight | 313.23 |
| Formula | C14H21BrN2O |
| CAS Number | 1648707-58-7 |
| Form | Viscous liquid |
| Solubility (25°C) | M;Ethanol 125 mg/mL (ultrasonic) DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
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