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UCN-02

Cat. No. M3799
UCN-02 Structure
Size Price Availability
2mg USD 180  USD200 Out of stock
5mg USD 324  USD360 Out of stock
10mg USD 522  USD580 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

UCN-02 is a stereoisomer of UCN-01. UCN-01 and UCN-02 showed the cytotoxic effect on the growth of HeLa S3 cells. UCN-02 is isolated as a minor co-metabolite of high staurosporine-producing strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 482.5
Formula C28H26N4O4
CAS Number 121569-61-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.
Takahashi I, et al. J Antibiot (Tokyo). 1989 Apr;42(4):571-6. PMID: 2656615.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UCN-02 supplier, PKC, inhibitors

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