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UCL 1684

Cat. No. M7449

All AbMole products are for research use only, cannot be used for human consumption.

UCL 1684 Structure

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Quality Control & Documentation
Biological Activity

UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.

Chemical Information
Molecular Weight 654.44
Formula C34H30Br2N4
CAS Number 199934-16-2
Solubility (25°C) DMSO 7.21 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chapman, et al. Br J Pharmacol. Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.

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Keywords: UCL 1684 supplier, inhibitors, activators

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