AG 879

Cat. No. M3098

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

Tyrphostin AG 879

Size	Price	Availability
5mg	USD 48 USD48	In stock
10mg	USD 75 USD75	In stock
25mg	USD 180 USD180	In stock

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Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.

Cell Experiment
Cell lines	MCF-7 cells
Preparation method	Growing cells in 96-well plates which is containing 100 μL medium per well. Ten microliters of MTT solution (5 mg/ml in PBS) is added to each well and incubation continued for 4 h at 37 °C. Subsequently, 100 μL 10% SDS in 0.01 M HCl is added. After incubation at 37°C overnight, absorption is measured at 550 nm in an ELISA reader using a reference filter of 690 nm.
Concentrations	20 μM
Incubation time	46 hours

Animal Experiment
Animal models	nude mice carrying v-Ha-RAS transformed NIH 3T3 cells
Formulation	30% dimethyl sulfoxide with PBS
Dosages	20 mg/kg
Administration	Intraperitoneally administrated on days 3, 5, 7, 10, 12, 14, and 17.

Molecular Weight	316.46
Formula	C18H24N2OS
CAS Number	148741-30-4
Solubility (25°C)	DMSO 25 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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