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TY 52156

Cat. No. M7438
TY 52156 Structure
Size Price Availability Quantity
10mg USD 139.5  USD155 In stock
50mg USD 540  USD600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

TY 52156 is an orally bioavailable s1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. TY 52156 suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. TY 52156 also inhibits S1P-induced breast cancer stem cell expansion in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 364.27
Formula C18H19Cl2N3O
CAS Number 934369-14-9
Purity >98%
Solubility DMSO 36.43 mg/mL
Storage at -20°C
References

Biochemical and antiproliferative properties of 4-[ar(alk)ylmino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor.
Fry, et al. Biochem Pharmacol. 1997;54: 877. PMID: 9354588.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TY 52156 supplier, S1P Receptor, inhibitors

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