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TSR-033

Cat. No. M25000

All AbMole products are for research use only, cannot be used for human consumption.

TSR-033 Structure

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Quality Control & Documentation
Biological Activity

TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity.

Chemical Information
CAS Number 2225940-96-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Matthew Ryan Sullivan, et al. Cell Death Dis. Quantifying the efficacy of checkpoint inhibitors on CD8+ cytotoxic T cells for immunotherapeutic applications via single-cell interaction

[2] Srimoyee Ghosh, et al. Mol Cancer Ther. TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo

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Keywords: TSR-033 supplier, inhibitors, activators

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