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TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals.
| Molecular Weight | 363.41 |
| Formula | C22H21NO4 |
| CAS Number | 667427-75-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 33.33 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1. |
| Phenazopyridine
Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine can promote neuronal differentiation and it can also be used in the research of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. |
| 4-ONE
4-ONE is one of the major hemolytic decomposition products of lipid hydroperoxides. 4-ONE is a potent transient receptor potential ankyrin 1 (TRPA1) agonist. |
| Moringin
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. |
| (S)-ABT-102
(S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin. |
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