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Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).
| Molecular Weight | 512.46 |
| Formula | C20H15F3N4O3.CH3SO3H |
| CAS Number | 147059-75-4 |
| Solubility (25°C) | Water 25.62 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Waring and Beaver. Gen Pharmacol. Gliotoxin and related epipolythiodioxopiperazines.
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