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Triptophenolide

Cat. No. M4199
Triptophenolide Structure
Synonym:

Hypolide; (+)-Triptophenolide

Size Price Availability Quantity
20mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Triptophenolide is a colorless crystal isolated from the ethyl acetate extract of Triptophenolide.

Chemical Information
Molecular Weight 312.40
Formula C20H24O3
CAS Number 74285-86-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yadi Song, et al. A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f

[2] Baowei Ma, et al. A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f

[3] Yang He, et al. Identification of Triptophenolide from Tripterygium wilfordii as a Pan-antagonist of Androgen Receptor

[4] Wen-Dan Xu, et al. Catalytic Asymmetric Formal Total Synthesis of (-)-Triptophenolide and (+)-Triptolide

[5] D Yang, et al. Enantioselective total synthesis of (-)-triptolide, (-)-triptonide, (+)-triptophenolide, and (+)-triptoquinonide

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Keywords: Triptophenolide, Hypolide; (+)-Triptophenolide supplier, Androgen Receptor, inhibitors, activators


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