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Trilaciclib hydrochloride

Cat. No. M11419
Trilaciclib hydrochloride Structure
Synonym:

G1T28 hydrochloride

Size Price Availability Quantity
5mg USD 550  USD550 In stock
10mg USD 800  USD800 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trilaciclib hydrochloride (G1T28 Hydrochloride) is an inhibitor of CDK4/6 with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 519.46988
Formula C24H32Cl2N8O
CAS Number 1977495-97-8
Purity >99%
Solubility Water ≥ 20 mg/mL
Storage 4°C , dry , sealed
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Keywords: Trilaciclib hydrochloride, G1T28 hydrochloride supplier, CDK, inhibitors

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