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Liothyronine

Cat. No. M6079

All AbMole products are for research use only, cannot be used for human consumption.

Liothyronine Structure
Synonym:

T3; 3,3',5-Triiodo-L-thyronine; L-3,3',5-Triiodothyronine; Tresitope

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 48  USD48 In stock
100mg USD 52  USD52 In stock
200mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Liothyronine (3,3',5-Triiodo-L-thyronine; T3) is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells.

This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution.

Chemical Information
Molecular Weight 650.97
Formula C15H12I3NO4
CAS Number 6893-02-3
Solubility (25°C) 1M NaOH : 50 mg/mL (ultrasonic and warming and heat to 60°C)
DMSO 40 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Timmer DC, et al. J Endocrinol. Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.

[2] Macchia PE, et al. Proc Natl Acad Sci U S A. Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.

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Keywords: Liothyronine, T3; 3,3',5-Triiodo-L-thyronine; L-3,3',5-Triiodothyronine; Tresitope supplier, Thyroid Hormone Receptor, inhibitors, activators

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